No correlation between changes in fatty acid-binding protein content and fatty acid oxidation capacity of rat tissues in experimental diabetes.

نویسندگان

  • J H Veerkamp
  • H T Van Moerkerk
  • J Van den Born
چکیده

Fatty acid-binding protein is considered to play an important role in fatty acid oxidation. Since diabetes mellitus causes marked changes of this latter metabolic process, we compared the effect of this pathological condition on both parameters in a comparative investigation of different rat tissues. Palmitate oxidation capacity and content of fatty acid-binding protein were determined in liver, heart and quadriceps muscle from rats with 2-week streptozotocin-induced diabetes mellitus and controls. In liver homogenates fatty acid oxidation capacity increased by 90%, but their content of fatty acid-binding protein decreased by 35%. Fatty acid oxidation capacity of heart and quadriceps muscle and fatty acid-binding protein content of quadriceps muscle did not change, but fatty acid-binding protein content of heart muscle doubled. Long-term diabetes (8 months) had a similar effect on content of this protein. In summary, changes of fatty acid oxidation capacity do not appear to correlate with fatty acid-binding protein content during the development of diabetes. This does not preclude other functions of fatty acid-binding proteins in regulation of lipid metabolism and processes in which fatty acids play a modulatory role.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Low Volume High Intensity Interval Training on Sarcolemmal Content of Fatty Acid Transport Proteins (FAT/CD36 and FABPpm) in Young Men

High-intensity interval training (HIT) induces skeletal muscle metabolic and performance adaptations that resemble traditional endurance training despite a low total exercise volume. On the other hand, fatty acid oxidation is increases in skeletal muscle with endurance training. This process is regulated in several sites, including the transport of fatty acids across the plasma membrane. The...

متن کامل

Effects of feed restriction and dietary fat type on mRNA expression of liver fatty acid-binding protein (L-FABP) in broilers

Background: Liver fatty acid-binding protein (L-FABP) is the main cytosolic binding site for long chain fatty acids in hepatocytes. FABPs enhance the uptake of fatty acids into the cell by increasing their concentration due to decreasing concentration of unbound fatty acids inside the cell. Objectives: The aim of this study was to evaluate the effects of dietary unsaturated to saturated fatty a...

متن کامل

یافته علمی کوتاه: بررسی تغییرات فصلی اسیدهای چرب در نرمتن Nerita textiles در مناطق جزر و مدی خلیج چابهار (دریای عمان)

The aim of this research was to identify and isolate the fatty acids composition of Nerita textiles in intertidal area of Chabahar Bay, and also to explore the seasonal changes of fatty acid content in Nerita textiles. GC/MS resulted thirteen fatty acids, that saturated fatty acids (SFA) of palmitic acid (16:0) was the most abundant category of fatty acid obtained in total lipids. There were no...

متن کامل

Effects of seasonal variations on fatty acid content of muscle in Pampus argenteus caught from Persian Gulf

Since fish have large amounts of long chain polyunsaturated fatty acids, they are considered a good source of food. In this study, fatty acid content and proximate composition of Silver Pomfret fish (Pampus argenteus) were investigated during winter and summer. For this purpose, the samples were collected from Bandar Lenge of Persian Gulf in 2016 and brought to the laboratory. The moisture, fat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The international journal of biochemistry & cell biology

دوره 28 4  شماره 

صفحات  -

تاریخ انتشار 1996